Tissue Engineered Scaffolds in Regenerative Medicine

Authors

Amir Manafi Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Davood Mehrabani Stem Cell and Transgenic Technology Research Center, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Hassan Karimfar Department of Anatomical Sciences, School of Medicine, Zahedan University of Medical sciences, Zahedan, Iran

Mohsen Hosseinkhani Department of Anatomical Sciences, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

Reza Shirazi Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Salar Bakhtiyari Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical sciences, Ilam, Iran

Abstract:

Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissue formation. Biodegradable scaffolds play an important role in creating a 3D environment to induce tissue formation. The application of scaffolding materials together with stem cell technologies are believed to hold enormous potential for tissue regeneration. In this review, we provide an overview of application of tissue engineered scaffolds and stem cells for the development of stem cell-based engineered tissue replacements. In particular, we focus on bone marrow stem cells (BMSCs) and mesenchymal stem cell (MSCs) due to their extensive clinical applications.

Upgrade to premium to download articles

Already have an account?login

similar resources

tissue engineered scaffolds in regenerative medicine

stem cells are self-renewing cells that can be differentiated into other cell types. conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2d) cultures. the design of three-dimensional (3d) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissu...

full text

Tissue-Engineered Products for Skin Regenerative Medicine

In a general wound healing process, foreign bodies and tissue detritus have to be broken down and then a new tissue is produced. However, the new tissue formation sometimes fails to proceed under the impaired conditions such as burn injury and intractable skin ulcer. A major obstruction to wound healing is infection. Another obstruction to wound healing is deficiency of growth factors. The endo...

full text

Decellularized scaffolds in regenerative medicine

Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosuppression, highlighting the importance of developing effective therapeutic strategies. In the field of regenerative medicine, various regenerative technologies have lately been developed using vario...

full text